Table 2 Allelic and genotypic distribution of TNFRSF1B polymorphisms among different study groups in North Indian population

(CA) _n

Allele

2n = 1,624

2n = 2,080

2n = 236

2n = 530

2n = 818

2n = 264

(CA)₁₁

96 (5.9)

155 (7.4)

15 (6.4)

39 (7.3)

62 (7.7)

16 (6.1)

(CA)₁₂

14 (0.9)

27 (1.3)

1 (0.4)

3 (0.6)

10 (1.2)

2 (0.7)

(CA)₁₃

304 (18.7)

390 (18.8)

41 (17.4)

99 (18.7)

164 (20.0)

46 (17.4)

(CA)₁₄

41 (2.5)

41 (2.0)

9 (3.8)

7 (1.3)

15 (1.8)

8 (3.0)

(CA)₁₅

885 (54.5)

1,129 (54.3)

128 (54.2)

301 (56.8)

436 (53.3)

147 (55.7)

(CA)₁₆

270 (16.6)

314 (15.1)

42 (17.8)

79 (14.9)

125 (15.3)

44 (16.7)

(CA)₁₇

14 (0.9)

24 (1.1)

0 (0.0)

2 (0.4)

6 (0.7)

1 (0.4)

OR (95% CI)*

1.01 (0.88–1.15)

0.90 (0.66–1.23)

0.90 (0.68–1.19)

P value

0.92

0.56

0.51

rs1061622

MAF, G

25.6

27.7

26.4

26.0

28.0

25.4

Genotype

n = 812

n = 1,026

n = 106

n = 265

n = 409

n = 130

GG

47 (5.8)

76 (7.4)

4 (3.8)

19 (7.2)

33 (8.1)

8 (6.1)

GT

321 (39.5)

417 (40.6)

48 (45.3)

100 (37.7)

163 (39.8)

50 (38.5)

TT

444 (54.7)

533 (51.9)

54 (50.9)

146 (55.1)

213 (52.1)

72 (55.4)

OR (95% CI)**

1.12 (0.93–1.34)

1.18 (0.75–1.85)

1.14 (0.77–1.70)

P value

0.25

0.54

0.58

rs3397

MAF, T

42.3

41.3

38.6

40.0

41.4

39.7

Genotype

n = 813

n = 1,030

n = 110

n = 265

n = 412

n = 131

TT

138 (17.0)

167 (16.2)

10 (9.1)

43 (16.2)

66 (16.0)

19 (14.5)

CT

412 (50.7)

516 (50.1)

65 (59.1)

126 (47.6)

209 (50.7)

66 (50.4)

CC

263 (32.3)

347 (33.7)

35 (31.8)

96 (36.2)

137 (33.3)

46 (35.1)

OR (95% CI)**

1.06 (0.87–1.29)

1.22 (0.75–1.95)

1.09 (0.72–1.64)

P value

0.61

0.49

0.77