Official Journal of the Human Genome Organisation
Table 3 Association between BRCA mutation carriers and non-carriers for personal and family history of breast and ovarian cancer by age
From: Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer
BRCA mutations | χ2 | P-value | Unadjusted | ||||||
|---|---|---|---|---|---|---|---|---|---|
Carriers (N = 28)* | Non-Carriers (N = 198)* | ||||||||
n | Col % | n | Col % | OR† | 95% CI | ||||
Family history | |||||||||
Whether family members had breast cancer: | |||||||||
<40 | No | 6 | 40.0 | 46 | 64.8 | 1.00** | |||
Yes | 9 | 60.0 | 25 | 35.2 | 3.18 | 0.07 | 2.76 | (0.88, 8.65) | |
≥40 | No | 3 | 25.0 | 70 | 55.6 | 1.00** | |||
Yes | 9 | 75.0 | 56 | 44.4 | 4.11 | 0.04 | 3.75 | (1.01, 14.51) | |
Whether family members had ovarian cancer: | |||||||||
<40 | No | 12 | 80.0 | 69 | 97.2 | 1.00** | |||
Yes | 3 | 20.0 | 2 | 2.8 | 6.68 | 0.04 | 8.63 | (1.30, 57.17) | |
≥40 | No | 10 | 83.3 | 118 | 93.7 | 1.00** | |||
Yes | 2 | 16.7 | 8 | 6.3 | 1.74 | 0.21 | 2.95 | (0.55, 15.81) | |