Deciphering modular and dynamic behaviors of transcriptional networks

The HUGO Journal

Official Journal of the Human Genome Organisation

Table 1 List of ligand-receptor pairs which showed differential coexpression between cancers and normal tissue

Ligand	Receptor	CoD-B		P_shuffle
Ligand	Receptor	Cancer	Normal	Cancer	Normal
(A) Lung cancer
BMP7	ACVR2B	0.76	0.00	0.028	0.58
EFNA3	EPHA5	0.84	0.00	6.7E-06	0.69
FGF8	FGFR2	0.55	0.00	1.5E-07	0.66
IL16	CD4	0.62	0.031	2.7E-06	0.68
CCL23	CCR1	0.00	0.85	0.73	2.1E-09
IL1RN	IL1R1	0.23	0.83	0.077	8.4E-07
IL18	IL18R1	0.18	0.71	0.097	4.5E-06
IL13	IL13RA2	0.00	0.69	0.62	1.5E-04
BMP5	BMPR2	0.00	0.61	0.69	1.7E-04
(B) Prostate cancer
BMP6	ACVR2B	0.63	0.081	0.0011	0.44
BTC	EGFR	0.75	0.00	1.7E-11	0.28
TGFB2	TGFBR2	0.79	0.00	3.5E-04	0.49
INHA	ACVR2A	0.59	0.019	1.1E-06	0.45
CCL23	CCR1	0.00	0.85	0.43	3.2E-09
IL1RN	IL1R1	0.00	0.82	0.32	3.1E-07
TNFSF8	TNFRSF8	0.00	0.76	0.36	1.5E-06
IL18	IL18R1	0.00	0.70	0.39	2.1E-07
FIGF	KDR	0.00	0.57	0.26	0.0023
CXCL5	IL8RB	0.00	0.58	0.41	1.1E-04
(C) Acute myeloid leukemia
FASLG	FAS	0.90	0.14	3.6E-05	0.34
BMP7	BMPR1B	0.82	0.00	7.7E-04	0.59
EFNA5	EPHA1	0.85	0.00	2.5E-04	0.71
FGF3	FGFR2	0.81	0.00	7.4E-06	0.66
FGF13	FGFR4	0.75	0.059	0.0097	0.47
NRG1	ERBB3	0.95	0.00	1.7E-05	0.28
CCL4	CCBP2	0.99	0.24	9.6E-06	0.062
CCL7	CCR5	0.97	0.29	0.00476	0.41
IFNA8	IFNAR2	0.88	0.00	2.9E-05	0.70
IFNG	IFNGR1	0.87	0.00	3.4E-04	0.68
IL13	IL4R	0.82	0.00	0.0041	0.70
INHBB	ACVR2B	0.82	0.23	1.5E-04	0.11
AMH	AMHR2	0.00	0.78	0.63	4.7E-05
CD40LG	CD40	0.00	0.97	0.33	8.6E-05
TNFSF7	TNFRSF7	0.39	0.97	0.043	8.2E-05
EFNA1	EPHA4	0.065	0.86	0.59	1.6E-06
FGF1	FGFR4	0.00	0.93	0.32	1.6E-06
CXCL2	IL8RB	0.25	0.84	0.33	3.3E-06
FGF17	FGFR3	0.17	0.70	0.17	3.0E-04
DLK1	NOTCH4	0.00	0.89	0.55	2.5E-07
TNFSF4	TNFRSF4	0.00	0.92	0.67	3.3E-04
CXCL9	CXCR3	0.30	0.98	0.054	1.5E-04
TGFB1	TGFBR1	0.00	0.71	0.62	6.8E-05