Table 3 Genes in Xp21-p22.3 deleted in the patient and included in OMIM morbid map

NLGN4 ^a

Neuroligin 4

X-linked mental retardation, autism

VCXA

Variably charged protein X-A

X-linked mental retardation

STS ^a

Steryl-sulfatase precursor

Ichtyosis

VCX

Variably charged protein X-B1

X-linked mental retardation

VCXB

Variably charged protein X-B

X-linked mental retardation

KAL1 ^a

Anosmin 1

Kallmann syndrome

TBL1X ^b

Transducin-beta-like-1

Possibly involved in the pathogenesis of ocular albinism with late-onset sensorineural deafness phenotype

GPR143 ^b

G protein-coupled receptor 143

Ocular albinism 1

MID1 ^b

Midline 1

Opitz/BBB syndrome

OFD1^a

Orofaciodigital syndrome type I

Orofaciodigital syndrome type I

FANCB ^c

Fanconi anemia complementation group B

Fanconi anemia

NHS ^b

Nance-Horan syndrome

Nance-Horan syndrome (congenital cataracts and dental anomalies)

STK9

Serine/threonine kinase-9

X-linked infantile spasm syndrome

RS1 ^b

Retinoschisis

Retinoschisis (X-linked, juvenile) 1

RPS6KA3 ^c

Ribosomal protein S6 kinase, 90-KD

X-linked mental retardation, Coffin-Lowry-syndrome

ARX

Aristaless related homeobox

X-linked mental retardation, hydranencephaly and abnormal genitalia

IL1RAPL1

Interleukin 1 receptor accessory protein-like 1

X-linked mental retardation