From evidence-based medicine to genomic medicine

The HUGO Journal

Official Journal of the Human Genome Organisation

Table 2 Genetic or genomic association in cardiovascular drug response

Drug/drug class	Gene(s) associated with toxicity or efficacy
β-agonists	β₂-receptors
β-blocker	β₁-receptor
	ACE
	Gs protein α subunit
	CYP2D6
ACE inhibitors	ACE
	Angiotensinogen
	AT₁ receptor
	Bradykinin B₂
Antiarrhythmics	Various congenital long QT syndrome genes
	N-acetyltransferase
	(Procainamide) CYP2D6
Antithrombotics
Abciximab	Platelet glycoprotein IIIa
Aspirin	Platelet glycoprotein IIIa
Heparin	Platelet Fc receptor
Warfarin	CYP2C9
AT₁-receptor blockers	AT₁ receptor
Digoxin	P-glycoprotein
Diuretics	G protein β₃ subunit
	α-adducing
Hydralazine	N-acetyltransferase
Lipid-lowering drugs
Statins	Apolipoprotein E
	Cholesterol ester transfer protein
	Stromelysin-1
	β-Fibrogen LDL receptor
	Lipoprotein lipase
	ACE
Gemfibrozil	Apolipoprotein E
	Stremelysin-1

ACE—angiotensin converting enzyme (adopted from Johnson and Cavallari 2005 with permission)