Official Journal of the Human Genome Organisation
From: Peripheral blood gene expression profiling for cardiovascular disease assessment
Indication | Target cell | Results | Ref |
---|---|---|---|
Dyslipidemia | Whole blood RNA | 895 genes correlated with LDL, 687 with HDL, and 364 with total cholesterol. 188 genes correlated both with LDL and total cholesterol. | (Ma et al. 2007) |
Essential hypertension | Whole blood RNA | 680 genes were found differentially expressed in untreated hypertensives compared to normotensive controls. On the other hand only 7 genes were differentially expressed in treated normotensives compared to normotensive controls. | (Chon et al. 2004) |
Type 2 Diabetes | Whole blood RNAa | Among the various pathways analyzed, 48 genes of JNK correlated with diabetes and glycemic control while 92 genes of OXPHOS correlated only with diabetes status irrespective of glycemic control. | (Takamura et al. 2007) |
Myocardial infarction | Platelet RNA | From >18,000 probe sets, 54 probe sets showed differential expression between STEMI and stable CAD. Moreover, MRP8/14 predicts risk of future cardiovascular event. | (Healy et al. 2006) |
Aortic Aneurysm | Whole blood RNA | A 41 gene signature identified between patients with aortic aneurysm and controls with 78% accuracy along with a sensitivity and specificity of 72% and 90% respectively. | (Wang et al. 2007) |
Venous Thromobo-embolism | Whole blood RNA | From 24, 650 genes profiled, 106 gene signature identified (1) patients with APS vs non-APS patients with VTE. (2) Predicticted likelihood of APS in patients with VTE. (3) Predicted likelihood of VTE in patients with aPLAs but not APS. | (Potti et al. 2006) |
Cardiac transplant | Whole blood RNA | From 252 genes profiled, an 11 gene test discriminated between moderate/severe rejection and quiescence. | (Deng et al. 2006) |
Pulmonary hypertension | Whole blood RNAa | A 106 gene signature identified with 95–100% accuracy patient with pulmonary hypertension versus controls. | (Bull et al. 2004) |