A novel computational and structural analysis of nsSNPs in CFTR gene

The HUGO Journal

Official Journal of the Human Genome Organisation

Table 1 List of nsSNPs that were predicted to be deleterious by SIFT and PolyPhen

SNPs ID	Alleles	AA change	Tolerance index	PSIC
rs1800072	G/A	V11C	1.00	0.150
rs1800073	C/T	R31C	0.18	2.288
rs1800074	A/T	D44V	0.01	2.532
rs1800076	G/A	R75Q	0.03	1.754
rs1800078	T/C	L138P	0.01	2.192
rs35516286	T/C	I148T	0.41	1.743
rs1800079	G/A	R170H	0.05	1.968
rs1800080	A/G	S182G	0.03	1.699
rs1800086	C/G	T351S	0.30	1.600
rs1800087	A/C	Q353H	0.03	2.093
rs4727853	C/A	N417K	1.00	0.015
rs11531593	C/A	F433L	0.65	0.694
rs1800089	C/T	L467F	0.15	1.568
rs213950	G/A	V470M	0.17	1.432
rs1800092	C/A/G	I506M	0.00	1.574
rs1801178	A/G	I507V	0.38	0.314
rs1800093	T/G	F508C	0.00	3.031
rs35032490	A/G	K532E	1.00	1.525
rs1800097	G/A	V562I	0.13	0.345
rs41290377	G/C	G576A	0.33	1.262
rs766874	C/T	S605F	0.03	2.147
rs1800099	A/G	S654G	0.03	1.611
rs1800100	C/T	R668C	0.01	2.654
rs1800101	T/C	F693L	0.61	0.895
rs1800103	A/G	I807M	0.01	1.554
rs1800106	T/C	Y903H	0.52	0.183
rs1800107	G/T	S909I	0.10	1.624
rs1800110	T/C	L967S	0.07	1.683
rs1800111	G/C	L997F	0.24	1.000
rs1800112	T/C	I1027T	0.03	1.860
rs1800114	C/T	A1067V	0.04	1.542
rs36210737	T/A	M1101K	0.05	2.637
rs35813506	G/A	R1102K	0.52	1.589
rs1800120	G/T	R1162L	0.00	2.038
rs1800123	C/T	T1220I	0.22	0.059
rs34911792	T/G	S1235R	0.45	1.483
rs11971167	G/A	D1270N	0.12	1.739
rs4148725	C/T	R1453W	0.00	2.513