Fig. 1

Association between specific genetic variants and study outcomes. The graphs show the association between the time to the first international normalized ratio (INR) within the therapeutic range and the time to the first INR of more than 4 for patients carrying genetic variants for vitamin K epoxide reductase (VKORC1) (Panels a and b) and for cytochrome P-450 2C9 (CYP2C9) (Panels c and d). Adapted with permission from The New England Journal of Medicine (Schwartz et al. N Engl J Med 358(10):999–1008, 2008)