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Official Journal of the Human Genome Organisation

Table 7 Clinical variables with statistical association with type 2 diabetes/coronary heart disease compound genotypes

From: Association of chromosome 9p21 SNPs with cardiovascular phenotypes in morbid obesity using electronic health record data

Variable

Total

L/L

M/L

H/L

L/M

L/H

M/M

H/M

M/H

H/H

DX HTNa

0.46

0.75

0.40

0.45

0.29

0.14

0.42

0.50

0.33

0.48

DX ERDb

0.25

0.00

0.37

0.23

0.07

0.14

0.27

0.25

0.16

0.28

DX DJDc

0.22

0.50

0.28

0.17

0.21

0.57

0.26

0.17

0.25

0.24

DX LOTHYRd

0.13

0.25

0.07

0.13

0.00

0.00

0.10

0.17

0.11

0.11

DX SOFTISSe

0.04

0.00

0.07

0.01

0.00

0.14

0.05

0.05

0.02

0.01

DX CHDf

0.02

0.00

0.02

0.00

0.00

0.00

0.03

0.03

0.07

0.02

DX BACKg

0.02

0.00

0.02

0.03

0.00

0.00

0.01

0.02

0.00

0.06

DX RESPh

0.02

0.00

0.00

0.03

0.00

0.00

0.04

0.01

0.05

0.02

DX NEUROTICi

0.04

0.00

0.00

0.02

0.00

0.00

0.03

0.06

0.02

0.03

MED NITRATESj

0.05

0.00

0.05

0.01

0.07

0.00

0.04

0.07

0.09

0.04

MED BENZOk

0.08

0.25

0.00

0.06

0.00

0.14

0.09

0.10

0.05

0.10

MED STER INHl

0.05

0.25

0.02

0.05

0.21

0.00

0.02

0.08

0.04

0.03

MED SNRIsm

0.06

0.25

0.09

0.02

0.00

0.00

0.08

0.06

0.04

0.09

MED TRICYCLICn

0.06

0.00

0.05

0.02

0.07

0.00

0.05

0.11

0.02

0.02

MED STATINSo

0.22

0.25

0.21

0.11

0.29

0.14

0.30

0.22

0.27

0.22

MED INT CHOLp

0.02

0.00

0.02

0.04

0.00

0.14

0.00

0.01

0.00

0.02

MED ANTI-HTNq

0.12

0.25

0.05

0.11

0.00

0.00

0.18

0.11

0.09

0.14

MED COLDr

0.04

0.00

0.00

0.07

0.07

0.29

0.04

0.02

0.00

0.04

MED THIAZIDEs

0.11

0.25

0.07

0.16

0.14

0.00

0.09

0.12

0.02

0.08

  1. L = low risk genotype, M = medium risk genotype, H = high risk genotype. Numbers represent proportion of patients with compound genotype that were diagnosed with indicated condition or were on indicated medication
  2. aDiagnosis-Hypertension
  3. bDiagnosis-Esophageal Reflux Disease
  4. cDiagnosis-Degenerative Joint Disease
  5. dDiagnosis-Hypothyroidism
  6. eDiagnosis-Soft Tissue Disorder
  7. fDiagnosis-Coronary Heart Disease
  8. gDiagnosis-Back Disorder
  9. hDiagnosis-Respiratory Disorder
  10. iDiagnosis-Neurotic Disorder
  11. jMedication-Nitrates
  12. kMedication-Benzodiazapines
  13. lMedication-Steroid Inhalants
  14. mMedication-Selective Serotonin Norepinephrine Reuptake Inhibitors
  15. nMedication-Tricyclic Antidepressants
  16. oMedication-HMG CoA Reductase Inhibitor Drugs
  17. pMedication-Intestinal Cholesterol Absorption Inhibitors
  18. qMedication-Anti-Hypertensives
  19. r Medication-Cold Remedies
  20. sMedication-Thiazide Diuretics