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Official Journal of the Human Genome Organisation

Table 2 Genes shown to be related to the prevalence of myocardial infarction or coronary heart disease

From: Molecular genetics of myocardial infarction

Chromosomal locus

Gene name

Gene symbol

References

1p36.3

5,10-Methylenetetrahydrofolate reductase

MTHFR

Gallagher et al. (1996) and Yamada et al. (2006)

1p36.2

Natriuretic peptide precursor A

NPPA

Gruchala et al. (2003)

1p35.1

Gap junction protein, alpha-4

GJA4

Yamada et al. (2002)

1p34.1-p32

Proprotein convertase, subtilisin/kexin-type, 9

PCSK9

Cohen et al. (2006)

1p34

Low density lipoprotein receptor-related protein 8, apolipoprotein E receptor

LRP8

Shen et al. (2007)

1p31.3-p31.2

Cytochrome P450, subfamily IIJ, polypeptide 2

CYP2J2

Liu et al. (2007)

1p22-p21

Coagulation factor III

F3

Ott et al. (2004)

1p22.1

Glutamate-cysteine ligase, modifier subunit

GCLM

Nakamura et al. (2002)

1q21-q23

C-reactive protein, pentraxin-related

CRP

Lange et al. (2006)

1q23-q25

Selectin E

SELE

Yoshida et al. (2003)

1q23-q25

Selectin P

SELP

Tregouet et al. (2002)

1q25

Tumor necrosis factor ligand superfamily, member 4

TNFSF4

Wang et al. (2005)

1q25.2-q25.3

Prostaglandin-endoperoxide synthase 2

PTGS2

Cipollone et al. (2004)

1q32

Complement factor H

CFH

Kardys et al. (2006)

1q42-q43

Angiotensinogen

AGT

Katsuya et al. (1995)

1q44

Olfactory receptor, family 13, subfamily G, member 1

OR13G1

Shiffman et al. (2005)

2p24

Apolipoprotein B

APOB

Hegele et al. (1986)

2p12-p11.2

Vesicle-associated membrane protein 8

VAMP8

Shiffman et al. (2006)

2q14

Interleukin 1-beta

IL1B

Iacoviello et al. (2005)

2q31

Collagen, type III, alpha-1

COL3A1

Muckian et al. (2002)

3pter-p21

Chemokine, CX3C motif, receptor 1

CX3CR1

Lavergne et al. (2005)

3p25

Peroxisome proliferator-activated receptor-gamma

PPARG

Ridker et al. (2003)

3p21

Chemokine, CC motif, receptor 2

CCR2

Ortlepp et al. (2003)

3p21

Chemokine, CC motif, receptor 5

CCR5

Gonzalez et al. (2001)

3q13.3-q21

Calcium-sensing receptor

CASR

Marz et al. (2007)

3q21-q25

Angiotensin receptor 1

AGTR1

Tiret et al. (1994)

3q26.3-q27

Thrombopoietin

THPO

Webb et al. (2001)

3q27

Adiponectin, C1Q, and collagen domain containing

ADIPOQ

Ohashi et al. (2004)

4q22-q24

Microsomal triglyceride transfer protein, 88-kD

MTTP

Ledmyr et al. (2004)

4q26-q28

Annexin A5

ANXA5

Gonzalez-Conejero et al. (2002)

4q28

Fibrinogen, B beta polypeptide

FGB

Behague et al. (1996)

4q28-q31

Fatty acid-binding protein 2

FABP2

Georgopoulos et al. (2007)

4q32.3

Palladin, cytoskeletal associated protein

PALLD

Shiffman et al. (2005)

5q13

Thrombospondin IV

THBS4

Topol et al. (2001)

5q23-q31

Integrin, alpha-2

ITGA2

Moshfegh et al. (1999)

5q31.1

Monocyte differentiation antigen CD14

CD14

Hubacek et al. (1999)

5q32-q34

Beta-2-adrenergic receptor

ADRB2

Sala et al. (2001)

5q33-qter

Factor XII

F12

Endler et al. (2001)

5q34

Potassium channel, calcium-activated, large conductance, subfamily M, beta member 1

KCNMB1

Senti et al. (2005)

6p25-p24

Factor XIII, A1 subunit

F13A1

Kohler et al. (1998)

6p21.3

Lymphotoxin-alpha

LTA

Ozaki et al. (2002)

6p21.3

Tumor necrosis factor

TNF

Vendrell et al. (2003)

6p21.2

Kinesin family member 6

KIF6

Iakoubova et al. (2008)

6p21.2-p12

Phospholipase A2, group VII

PLA2G7

Yamada et al. (1998)

6p12

Glutamate-cysteine ligase, catalytic subunit

GCLC

Koide et al. (2003)

6p12

Vascular endothelial growth factor

VEGF

Howell et al. (2005)

6q22

c-Ros oncogene 1, receptor tyrosine kinase

ROS1

Shiffman et al. (2005)

6q22-q23

Ectonucleotide pyrophosphatase/phosphodiesterase 1

ENPP1

Bacci et al. (2005)

6q23

Arginase, liver

ARG1

Dumont et al. (2007)

6q25.1

Estrogen receptor 1

ESR1

Shearman et al. (2003)

6q25.3

Superoxide dismutase 2, mitochondrial

SOD2

Fujimoto et al. (2008)

6q26

Lipoprotein(a)

LPA

Holmer et al. (2003)

6q27

Thrombospondin II

THBS2

Topol et al. (2001)

7p21

Interleukin 6

IL6

Georges et al. (2001)

7q21.3

Paraoxonase 1

PON1

Serrato and Marian (1995)

7q21.3-q22

Plasminogen activator inhibitor 1

PAI1

Eriksson et al. (1995) and Yamada et al. (2002)

7q36

Nitric oxide synthase 3

NOS3

Shimasaki et al. (1998)

8p22

Lipoprotein lipase

LPL

Jemaa et al. (1995) and Yamada et al. (2006)

8p12

Plasminogen activator, tissue

PLAT

Ladenvall et al. (2002)

9p21.3

Cyclin-dependent kinase inhibitor 2A/B

CDKN2A/B (?)

Helgadottir et al. (2007), McPherson et al. (2007), Samani et al. (2007) and Wellcome Trust Case Control Consortium 2007

9q22-q31

ATP-binding cassette, subfamily A, member 1

ABCA1

Tregouet et al. (2004)

9q32-q33

Toll-like receptor 4

TLR4

Edfeldt et al. (2004)

10q24-q26

Beta-1-adrenergic receptor

ADRB1

Iwai et al. (2003)

11q22-q23

Matrix metalloproteinase 1

MMP1

Pearce et al. (2005)

11q23

Apolipoprotein A-V

APOA5

Talmud et al. (2004)

11q23

Apolipoprotein C-III

APOC3

Olivieri et al. (2002)

11q23

Matrix metalloproteinase 3

MMP3

Yamada et al. (2002) and Ye et al. (1995)

12p13.2

Taste receptor, type 2, member 50

TAS2R50

Shiffman et al. (2008)

12p13

Guanine nucleotide-binding protein, beta-3

GNB3

Naber et al. (2000)

12p13-p12

Low density lipoprotein, oxidized, receptor 1

OLR1

Mango et al. (2005)

12q22

Leukotriene A4 hydrolase

LTA4H

Helgadottir et al. (2006)

13q12

Arachidonate 5-lipoxygenase-activating protein

ALOX5AP

Helgadottir et al. (2004)

13q12.1

Insulin promoter factor 1

IPF1

Yamada et al. (2006)

13q14.11

Carboxypeptidase B2, plasma

CPB2

Juhan-Vague et al. (2002)

13q34

Factor VII

F7

Iacoviello et al. (1998)

13q34

Collagen, type IV, alpha 1

COL4A1

Yamada et al. (2008)

14q13

Proteasome subunit, alpha-type, 6

PSMA6

Ozaki et al. (2006)

15q15

Thrombospondin I

THBS1

Zwicker et al. (2006)

15q21-q23

Lipase, hepatic

LIPC

Dugi et al. (2001)

16p13.3

Deoxyribonuclease I

DNASE1

Kumamoto et al. (2006)

16p13

Major histocompatibility complex, class II, transactivator

MHC2TA

Swanberg et al. (2005)

16p11.2

Vitamin K epoxide reductase complex, subunit 1

VKORC1

Wang et al. (2006)

16q13

Matrix metalloproteinase 2

MMP2

Vasku et al. (2004)

16q21

Cholesteryl ester transfer protein, plasma

CETP

Kuivenhoven et al. (1998)

16q24

Cytochrome b(-245), alpha subunit

CYBA

Inoue et al. (1998)

17pter-p12

Glycoprotein Ib, platelet, alpha polypeptide

GP1BA

Murata et al. (1997)

17p13

Chemokine, CXC motif, ligand 16

CXCL16

Lundberg et al. (2005)

17q11.1-q12

Solute carrier family 6, member 4

SLC6A4

Fumeron et al. (2002)

17q11.2-q12

Chemokine, CC motif, ligand 2

CCL2

McDermott et al. (2005)

17q21.1-q21.2

Chemokine, CC motif, ligand 11

CCL11

Zee et al. (2004)

17q21.32

Integrin, beta-3

ITGB3

Weiss et al. (1996)

17q23

Angiotensin I-converting enzyme

ACE

Cambien et al. (1992)

17q23

Platelet-endothelial cell adhesion molecule 1

PECAM1

Elrayess et al. (2004)

19p13

Purinergic receptor P2Y, G protein-coupled, 11

P2RY11

Amisten et al. (2007)

19p13.3-p13.2

Intercellular adhesion molecule 1

ICAM1

Podgoreanu et al. (2006)

19p13.2

Zinc finger protein 627

ZNF627

Shiffman et al. (2005) and Yamada et al. (2008)

19q13.1

Transforming growth factor, beta 1

TGFB1

Yokota et al. (2000)

19q13.2

Apolipoprotein E

APOE

Wilson et al. (1994)

19q13.2

Heterogeneous nuclear ribonucleoprotein U-like 1

HNRPUL1

Shiffman et al. (2006)

19q13.4

Glycoprotein VI, platelet

GP6

Croft et al. (2001)

19q13.4

Fc fragment of IgA, receptor for

FCAR

Iakoubova et al. (2006)

20p11.2

Thrombomodulin

THBD

Wu et al. (2001)

20q11.2-q13.1

Matrix metalloproteinase 9

MMP9

Zhang et al. (1999)

20q13.11-q13.13

Prostaglandin I2 synthase

PTGIS

Nakayama et al. (2002)

21q21.2

ADAM metallopeptidase with thrombospondin type 1 motif, 1

ADAMTS1

Sabatine et al. (2008)

22q11.2

Catechol-O-methyltransferase

COMT

Eriksson et al. (2004)

22q12

Heme oxygenase 1

HMOX1

Ono et al. (2004)

22q12-q13

Lectin, galactoside-binding, soluble, 2

LGALS2

Ozaki et al. (2004)