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Official Journal of the Human Genome Organisation

Table 1 Numbers of genes in various functional classes included in this study

From: Genetic determinants of immune-response to a polysaccharide vaccine for typhoid

GO categorya

Molecular function

No. of genes

GO:0004871

Signal transducer activity

86

GO:0005102

Receptor binding

44

GO:0001664

G-protein-coupled receptor binding

41

GO:0003676

Nucleic acid binding

21

GO:0000166

Nucleotide binding

19

GO:0001584

Rhodopsin-like receptor activity

16

GO:0005488

Binding

12

GO:0003824

Catalytic activity

7

GO:0004857

Enzyme inhibitor activity

6

GO:0003823

Antigen binding

3

GO:0001871

Pattern binding

3

GO:0001530

Lipopolysaccharide binding

2

GO:0008009

Chemokine activity

1

GO:0001948

Glycoprotein binding

1

GO:0015457

Auxiliary transport protein activity

1

GO:0032393

MHC class I receptor activity

1

GO:0003774

Motor activity

1

GO:0032395

MHC class II receptor activity

1

GO:0001532

Interleukin-21 receptor activity

1

GO:0005125

Cytokine activity

1

GO:0000287

Magnesium ion binding

1

GO:0005048

Signal sequence binding

1

GO:0005515

Protein binding

1

GO:0001540

Beta-amyloid binding

1

GO:0005215

Transporter activity

1

GO:0003712

Transcription cofactor activity

1

Miscellaneous (GO category unavailable; information obtained from UNIPROTb database)

Mediation of inflammation and angiogenesis

1

Peptide binding

1

Antimicrobial activity

3

T-cell activation

1

Defense response with MHC

1

Regulation of inflammatory responses

1

Putative immune function (Gene: HCG9; lies within MHC class I region)

1

Total

283

  1. aGO (Gene Ontology) category was obtained from gene2go file of NCBI Entrez Gene database (ftp://ftp.ncbi.nlm.nih.gov/gene/DATA/)
  2. b(http://www.uniprot.org/)