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Official Journal of the Human Genome Organisation

Table 2 Association of BRCA mutation carriers and non-carriers and family history of breast and ovarian cancers

From: Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer

 

BRCA Mutations

Carriers (N = 28)*

Non-carriers (N = 198)*

  

Unadjusted

n

Col %

n

Col %

χ2

P-value

OR†

95% CI

Family history

Whether family members had any cancer:

 No

3

10.7

53

26.8

  

1.00**

 

 Yes

25

89.3

145

73.2

3.39

0.07

3.05

(0.88, 10.51)

Type of cancer for family members

Breast cancer:

 No

9

32.1

116

58.6

  

1.00**

 

 Yes

19

67.9

82

41.4

6.94

0.01

2.99

(1.29, 6.93)

Ovarian cancer:

 No

22

78.6

188

94.9

  

1.00**

 

 Yes

6

21.4

10

5.1

10.00

0.002

5.13

(1.70, 15.47)

Breast cancer (among families with breast cancer, n = 101)

No. of family member had breast cancer:

 1

5

26.3

64

78.0

  

1.00**

 

 2

8

42.1

15

18.3

 

0.003

6.83

(1.95, 23.85)

 ≥3

6

31.6

3

3.7

22.47

<0.001

25.60

(4.88, 134.4)

No. of 1st degree relative had breast cancer:

 0

1

5.3

25

30.5

  

1.00**

 

 1

7

36.8

46

56.1

 

0.22

3.80

(0.44, 32.70)

 ≥2

11

57.9

11

14.4

19.25

0.004

25.00

(2.87, 218.2)

No. of 2nd degree relative had breast cancer:

 0

12

63.2

58

70.7

  

1.00**

 

 1

5

26.3

20

24.4

 

0.75

1.21

(0.38, 3.86)

 2

2

10.5

4

4.9

0.76

0.34

2.42

(0.40, 14.73)

  1. Bold figure: significant at <0.05
  2. * Values may not sum to 100% because of missing data
  3. ** Referent
  4. † Univariate Odd Ratios comparing “Carriers” versus “Non-carriers” (reference group)