Official Journal of the Human Genome Organisation
From: Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer
BRCA Mutations | ||||||||
---|---|---|---|---|---|---|---|---|
Carriers (N = 28)* | Non-carriers (N = 198)* | Unadjusted | ||||||
n | Col % | n | Col % | χ2 | P-value | OR† | 95% CI | |
Family history | ||||||||
Whether family members had any cancer: | ||||||||
No | 3 | 10.7 | 53 | 26.8 | 1.00** | |||
Yes | 25 | 89.3 | 145 | 73.2 | 3.39 | 0.07 | 3.05 | (0.88, 10.51) |
Type of cancer for family members | ||||||||
Breast cancer: | ||||||||
No | 9 | 32.1 | 116 | 58.6 | 1.00** | |||
Yes | 19 | 67.9 | 82 | 41.4 | 6.94 | 0.01 | 2.99 | (1.29, 6.93) |
Ovarian cancer: | ||||||||
No | 22 | 78.6 | 188 | 94.9 | 1.00** | |||
Yes | 6 | 21.4 | 10 | 5.1 | 10.00 | 0.002 | 5.13 | (1.70, 15.47) |
Breast cancer (among families with breast cancer, n = 101) | ||||||||
No. of family member had breast cancer: | ||||||||
1 | 5 | 26.3 | 64 | 78.0 | 1.00** | |||
2 | 8 | 42.1 | 15 | 18.3 | 0.003 | 6.83 | (1.95, 23.85) | |
≥3 | 6 | 31.6 | 3 | 3.7 | 22.47 | <0.001 | 25.60 | (4.88, 134.4) |
No. of 1st degree relative had breast cancer: | ||||||||
0 | 1 | 5.3 | 25 | 30.5 | 1.00** | |||
1 | 7 | 36.8 | 46 | 56.1 | 0.22 | 3.80 | (0.44, 32.70) | |
≥2 | 11 | 57.9 | 11 | 14.4 | 19.25 | 0.004 | 25.00 | (2.87, 218.2) |
No. of 2nd degree relative had breast cancer: | ||||||||
0 | 12 | 63.2 | 58 | 70.7 | 1.00** | |||
1 | 5 | 26.3 | 20 | 24.4 | 0.75 | 1.21 | (0.38, 3.86) | |
2 | 2 | 10.5 | 4 | 4.9 | 0.76 | 0.34 | 2.42 | (0.40, 14.73) |