Fig. 2From: Germ-line variation at a functional p53 binding site increases susceptibility to breast cancer developmentFunctional analysis of the binding site sequence (226 bp fragment) and its polymorphism (rs1860746) by reporter gene assay in wild-type and p53-null HCT116 cells with or without 5FU treatment. Control TATA-luciferase pGL4 vector; G_TATA TATA-luciferase pGL4 vector with a insert of the 226 bp binding site sequence of G allele; T_TATA TATA-luciferase pGL4 vector with a insert of the 226 bp binding site sequence of T alleleBack to article page