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Official Journal of the Human Genome Organisation

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Fig. 2 | The HUGO Journal

Fig. 2

From: Germ-line variation at a functional p53 binding site increases susceptibility to breast cancer development

Fig. 2

Functional analysis of the binding site sequence (226 bp fragment) and its polymorphism (rs1860746) by reporter gene assay in wild-type and p53-null HCT116 cells with or without 5FU treatment. Control TATA-luciferase pGL4 vector; G_TATA TATA-luciferase pGL4 vector with a insert of the 226 bp binding site sequence of G allele; T_TATA TATA-luciferase pGL4 vector with a insert of the 226 bp binding site sequence of T allele

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