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Official Journal of the Human Genome Organisation

Table 2 Analysis of the association of SNP with cancer susceptibility under a recessive model of inheritance in the combined Swedish and Finnish samples

From: Germ-line variation at a functional p53 binding site increases susceptibility to breast cancer development

Sample

Size

Genotype Freq (%)

OR (95% CI)

P value

GG or GT

TT

Controls

2,739

97.08

2.92

  

All cases

3,512

96.07

3.93

1.34 (1.01, 1.77)

0.04

ER+ cases

2,492

96.27

3.73

1.26 (0.92, 1.72)

0.15

ER− cases

588

95.58

4.42

1.48 (0.93, 2.35)

0.10

Postmenopausal cases

2,447

96.24

3.76

1.30 (0.96, 1.76)

0.10

Premenopausal cases

502

94.82

5.18

1.66 (1.00, 2.75)

0.05

Sporadic cases

2,359

96.31

3.69

1.25 (0.92, 1.70)

0.16

Familial cases

1,098

95.72

4.28

1.48 (1.01, 2.17)

0.04