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The HUGO Journal

Official Journal of the Human Genome Organisation

Fig. 5 | The HUGO Journal

Fig. 5

From: Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing

Fig. 5

Nucleosome structures in regions surrounding HIF-1α binding sites. Nucleosome occupancy in regions surrounding the identified HIF-1α binding sites. The calculated nucleosome occupancy scores (y-axis) are plotted against every genomic coordinate (x-axis). The computational procedure used to calculate the nucleosome occupancy score is described in “Materials and methods”. The putative binding site of HIF-1α, represented by HRE, was defined as position 0 (x-axis). Blue and red lines indicate the nucleosome occupancy scores under hypoxia and normoxia, respectively. Only the HIF-1α binding sites for which the associated TSCs were induced by more than twofold were used in the plot for each cell type. For details regarding the Nucleosome-Seq datasets, see Supplementary Fig. 9. (Color figure online)

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