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The HUGO Journal

Official Journal of the Human Genome Organisation

Table 1 Number of HIF-1α binding sites

From: Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing

 

Hypoxia-responsive binding sites

Non-hypoxia-responsive binding sites

Hypoxia-specific

Hypoxia-enriched

Total binding sites

Sites containing HRE

DLD-1

499

32

531

441 (83%)

35

TIG-3

599

17

616

413 (67%)

54

  1. The number of identified HIF-1α binding sites in DLD-1 and TIG-3 cells. “Hypoxic-responsive” HIF-1α binding sites are the sum of the “hypoxia-specific” binding sites, which were detected only under hypoxia, and the “hypoxia-induced” binding sites, which were detected under normoxia, but the ChIP-Seq tag concentration was induced more than twofold under hypoxia. Note that most of the identified “hypoxia-responsive” HIF-1α binding sites are “hypoxia-specific.” HRE hypoxia response element, 5′-RCGTG-3′
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