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Official Journal of the Human Genome Organisation

Table 2 Number of TSCs associated with binding sites located in genic and intergenic regions

From: Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing

 

#Binding sites

#HIF-1α bound genes in which TSCs overlapped the 5′-end of RefSeq transcript models

#HIF-1α target genes

a

 DLD-1

193

220

121

 TIG-3

161

185

48

 

#Previously characterized AP TSCs (#genes)

#Newly identified AP TSCs (#genes)

b

 DLD-1

15 (15)

193 (89)

 TIG-3

5 (4)

123 (80)

 

#Binding sites

#Intergenic TSCs

#Intergenic TSCs located in repetitive regions

c

 DLD-1

207

262

21

 TIG-3

289

105

21

  1. aThe number of genes that were bound to HIF-1α in the flanking regions (from 10 kb upstream to 1 kb downstream of the binding sites) of the 5′-ends in the RefSeq transcript models. “HIF-1α target genes” indicate genes with expression levels that were induced more than twofold by hypoxia
  2. b The number of HIF-1α target TSCs corresponding to alternative promoters (APs) which had been characterized as RefSeq transcript variants (first column) and those which were newly identified in this study (second column). The numbers of corresponding genes are shown in parentheses
  3. c The number of HIF-1α target TSCs located in intergenic regions