Haplotype variation in the ACE gene in global populations, with special reference to India, and an alternative model of evolution of haplotypes

The HUGO Journal

Official Journal of the Human Genome Organisation

Table 2 Percentage frequencies of haplotypes (major haplotypes in bold) in Indian, Africans, and Caucasian population

No	Populations→		AGH	BAG	HO	TTO	JAM	MZO	SBR	SNM	MUR	IYR	IYN	KAD	KMN	PLN	Caucasian	Nigerian	Jamaican	Afro-Am
	Haplotype↓	Language→ Location→	IE	IE	AA	TB	TB	TB	IE	IE	DR	DR	DR	DR	DR	DR	Europe (Britain)	W Africa (Nigeria)	Caribbean Islands	USA
	Haplotype↓	Language→ Location→	East India				Northeast India		Central India			South India					Europe (Britain)	W Africa (Nigeria)	Caribbean Islands	USA
1	TATATTGIA		38	60	72	55	65	55	52	50	55	45	53	68	42	52	40	2	3	8
2	CCCTCCADG		36	19	18	40	32	35	38	33	33	25	33	18	40	27	28	2	5	6
3	TATATTADG		10	0	0	0	0	0	0	0	3	9	0	5	2	5	0	0	0	0
4	TATATCADG		5	7	0	0	0	0	2	2	2	3	0	0	2	0	9	0	0	0
5	CCCTTCGIA		3	6	5	0	0	0	2	0	2	10	2	0	3	2	0	19	14	12
6	TATATTGDA		2	0	0	3	0	0	0	0	0	0	2	0	0	0	0	0	0	0
7	TATTCCADG		2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
8	CCCACCGDA		2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
9	CCCTTCADG		2	2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
10	CCCTCTADG		0	2	0	0	0	0	0	0	2	0	0	0	0	0	0	0	0	0
11	TACATTGIA		0	2	0	0	0	0	0	2	0	5	0	2	0	0	0	0	0	0
12	TACATCADG		0	1	0	0	0	0	2	5	0	5	7	3	2	2	7	16	32	36
13	CCCTTTGIA		0	1	0	0	0	0	0	0	0	0	0	0	0	0	3	0	0	0
14	CCCTCCGDG		0	0	3	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
15	TATATCGIA		0	0	2	0	0	0	0	0	0	0	3	0	3	3	0	0	0	0
16	CCCTCCGIA		0	0	0	0	2	0	0	2	0	2	0	0	5	0	0	0	0	0
17	TATATCADA		0	0	0	0	0	0	0	0	0	0	0	0	0	2	0	0	0	0
18	CACTCCADG		0	0	0	0	0	0	2	0	0	0	0	0	0	0	0	0	2	0
19	CCTATTGIA		0	0	0	0	0	0	0	0	0	0	2	0	0	0	0	0	0	0
19	TACATCADA		0	0	0	0	0	0	0	0	2	0	0	3	2	0	0	29	23	25
20	CCCTCCAIG		0	0	0	2	0	0	0	3	0	0	0	0	2	0	0	0	0	0
21	TATATTGDG		0	0	0	0	0	0	0	0	2	0	0	0	0	0	0	0	0	0
22	CCCTCTGIA		0	0	0	0	0	2	0	0	0	0	0	0	0	3	0	0	0	0
23	CCTTCCADG		0	0	0	0	0	0	0	0	0	0	0	0	0	2	0	0	0	0
24	CCCACCGIA		0	0	0	0	0	0	0	0	0	0	0	0	0	2	0	0	0	0
25	TATTTCADG		0	0	0	0	0	0	0	0	0	0	0	0	0	2	0	0	0	0
26	TATATTAIA		0	0	0	0	0	0	0	0	0	0	0	0	0	0	3	0	0	0
27	TACATCGIA		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2	3	3
28	CATATTGIA		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2	2	2
29	TCCATTGIA		0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2	0	2

IE Indo-European, DR Dravidian, AA Austro-Asiatic and TB Tibeto-Burman refer to the linguistic affiliations of the Indian populations
The percentages do total to 100 as haplotypes with frequency below 1% were excluded