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The HUGO Journal

Official Journal of the Human Genome Organisation

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Articles

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  37. Respiratory syncytial virus (RSV) infection involves complex virus-host interplay. In this study, we analyzed gene expression in RSV-infected BEAS-2B cells to discover novel signaling pathways and biomarkers. ...

    Authors: Yuh-Chin T. Huang, Zhuowei Li, Xhevahire Hyseni, Michael Schmitt, Robert B. Devlin, Edward D. Karoly and Joleen M. Soukup
    Citation: Genomic Medicine 2009 2:9080
    Content type: Research Article Published on:

  38. Pharmacogenetic tests allow medications to be tailored to individual patients to improve efficacy and reduce drug toxicity. In 2005, the International Society of Pharmacogenomics (ISP) made recommendations for...

    Authors: Jenny E. Higgs, Julie Andrews, David Gurwitz, Katherine Payne and William Newman
    Citation: Genomic Medicine 2009 2:9032
    Content type: Research Article Published on:

  39. Inflammation plays a crucial role in the pathogenesis of type 2 diabetes and various lines of evidences suggest an important contribution of type 2 receptor for TNFα (TNFR2), a mediator of inflammatory responses....

    Authors: Rubina Tabassum, Sreenivas Chavali, Anubha Mahajan, Saurabh Ghosh, S. V. Madhu, Nikhil Tandon and Dwaipayan Bharadwaj
    Citation: Genomic Medicine 2009 2:9031
    Content type: Research Article Published on:

  40. Background/aims Several studies have reported varying results of the influence of ACE gene on ACEI/ARB therapy. The efficacy of high dose ARB and its influence on ACE gene have not been explored. This is a 6 year...

    Authors: Keng-Thye Woo, Choong-Meng Chan, Hui-Lin Choong, Han-Kim Tan, Marjorie Foo, Evan J. C. Lee, Chorh-Chuan Tan, Grace S. L. Lee, Seng-Hoe Tan, A. Vathsala, Cheng-Hong Lim, Gilbert S. C. Chiang, Stephanie Fook-Chong, Zhao Yi, H. B. Tan and Kok-Seng Wong
    Citation: Genomic Medicine 2009 2:9030
    Content type: Research Article Published on:

  41. Genetic diseases are recognized to be one of the major categories of human disease. Traditionally genetic diseases are subdivided into chromosomal (numerical or structural aberrations), monogenic or Mendelian ...

    Authors: Dhavendra Kumar
    Citation: Genomic Medicine 2009 2:9028
    Content type: Review article Published on:

  43. The unique case of two sisters with symptoms of RTT and two quite distinct, novel, and apparently de novo microdeletions of the MECP2 gene is described. One sister possessed an 18 base-pair (bp) deletion (c.1155_...

    Authors: Lyndon G. Rosser, Shane McKee, David S. Millar, Hayley Archer, James Hughes, Rachel Butler, Nadia Chuzhanova, David N. Cooper and Lazarus P. Lazarou
    Citation: Genomic Medicine 2008 2:9026
    Content type: Research Article Published on:

  44. Myocardial infarction (MI) is an important clinical problem because of its large contribution to mortality. The main causal and treatable risk factors for MI include hypertension, hypercholesterolemia or dysli...

    Authors: Yoshiji Yamada, Sahoko Ichihara and Tamotsu Nishida
    Citation: Genomic Medicine 2008 2:9025
    Content type: Review Published on:

  45. Cleidocranial dysplasia (CCD; MIM 119600) is a rare autosomal dominant disorder characterized by facial, dental, and skeletal malformations. To date, rearrangement and mutations involving RUNX2, which encodes a t...

    Authors: Ming Ta Michael Lee, Anne Chun-Hui Tsai, Ching-Heng Chou, Feng-Mei Sun, Li-Chen Huang, Pauline Yen, Chyi-Chyang Lin, Chih-Yang Liu, Jer-Yuarn Wu, Yuan-Tsong Chen and Fuu-Jen Tsai
    Citation: Genomic Medicine 2008 2:9024
    Content type: Research Article Published on:

  46. Genomic medicine research requires substantial time and resources to obtain phenotype data. The electronic health record offers potential efficiencies in addressing these temporal and economic challenges, but ...

    Authors: G. Craig Wood, Christopher D. Still, Xin Chu, Meghan Susek, Robert Erdman, Christina Hartman, Stephanie Yeager, Mary Ann Blosky, Wanda Krum, David J. Carey, Kimberly A. Skelding, Peter Benotti, Walter F. Stewart and Glenn S. Gerhard
    Citation: Genomic Medicine 2008 2:9023
    Content type: Research Article Published on:

  49. Individual genomics has arrived, personal decisions to make use of it are a new reality. What are the implications for the patient–physician relationship? In this article we address three factors that call the...

    Authors: Jeantine E. Lunshof, Ruth Chadwick and George M. Church
    Citation: Genomic Medicine 2008 2:9020
    Content type: Editorial Published on:

  50. Single Nucleotide Polymorphisms (SNPs) are being intensively studied to understand the biological basis of complex traits and diseases. The Genetics of human phenotype variation could be understood by knowing ...

    Authors: C. George Priya Doss, R. Rajasekaran, C. Sudandiradoss, K. Ramanathan, R. Purohit and R. Sethumadhavan
    Citation: Genomic Medicine 2008 2:9019
    Content type: Research Article Published on: