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The HUGO Journal

Official Journal of the Human Genome Organisation

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Articles

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  1. 5α-Androstane-3α,17β-diol (3α-diol) is reduced from the potent androgen, 5α-dihydrotestosterone (5α-DHT), by reductive 3α-hydroxysteroid dehydrogenases (3α-HSDs) in the prostate. 3α-diol is recognized as a wea...

    Authors: Mikhail G. Dozmorov, Qing Yang, Adam Matwalli, Robert E. Hurst, Daniel J. Culkin, Bradley P. Kropp and Hsueh-Kung Lin
    Citation: Genomic Medicine 2008 1:9018
    Content type: Research Article Published on:

  6. The concept of ‘evidence-based medicine’ dates back to mid-19th century or even earlier. It remains pivotal in planning, funding and in delivering the health care. Clinicians, public health practitioners, heal...

    Authors: Dhavendra Kumar
    Citation: Genomic Medicine 2007 1:9013
    Content type: Review Published on:

  8. A highly-parallel yeast functional assay, capable of screening approximately 100–1,000 mutants in parallel and designed to screen the activity of transcription activator proteins, was utilized to functionally ...

    Authors: Joshua Merritt, Kim G. Roberts, James A. Butz and Jeremy S. Edwards
    Citation: Genomic Medicine 2007 1:9011
    Content type: Research Article Published on:

  9. Hyperproliferative epidermal disorders range from benign hyperplasias such as psoriasis to basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), the two most common cancers in the US. While they all ar...

    Authors: Min Fang, Sue Ann Wee, Karyn Ronski, Hongran Fan, Shiying Tao and Qun Lin
    Citation: Genomic Medicine 2007 1:9010
    Content type: Research Article Published on:

  10. We report on a patient with severe mental retardation, dysmorphic features as well as juvenile idiopathic arthritis. G-banding indicated two independent karyotypic anomalies in this patient: an interstitial de...

    Authors: Sabine Leybrand, Eva Rossier, Gotthold Barbi, David N. Cooper and Hildegard Kehrer-Sawatzki
    Citation: Genomic Medicine 2007 1:9008
    Content type: Research Article Published on:

  12. Array based comparative genomic hybridisation (aCGH) is a powerful technique for detecting clinically relevant genome imbalance and can offer 40 to > 1000 times the resolution of karyotyping. Indeed, idiopathi...

    Authors: Sarah Wordsworth, James Buchanan, Regina Regan, Val Davison, Kim Smith, Sara Dyer, Carolyn Campbell, Edward Blair, Eddy Maher, Jenny Taylor and Samantha J. L. Knight
    Citation: Genomic Medicine 2007 1:9005
    Content type: Research Article Published on:

  13. Protein p53 is the tumor suppressor involved in cell cycle control and apoptosis. There are several polymorphisms reported for p53 which can affect important regions involved in protein tumor suppressor activi...

    Authors: Diogo André Pilger, Patrícia Luciana da Costa Lopez, Fábio Segal and Sandra Leistner-Segal
    Citation: Genomic Medicine 2007 1:9007
    Content type: Research Article Published on:

  14. The present study focuses on the application of a therapeutic strategy in patients with chronic severe lower limb ischaemia using a plasmid vector encoding the vascular endothelial growth factor (phVEGF165). It h...

    Authors: Andrei Anghel, Bogdan Mut-Vitcu, Lorand Savu, Catalin Marian, Edward Seclaman, Raluca Iman, Adriana-Maria Neghina and Stefan I. Dragulescu
    Citation: Genomic Medicine 2007 1:9006
    Content type: Research Article Published on:

  18. LINE-1 or L1 has driven the generation of at least 10% of the human genome by mobilising Alu sequences. Although there is no doubt that Alu insertion is initiated by L1-dependent target site-primed reverse transc...

    Authors: Jian-Min Chen, Claude Férec and David N. Cooper
    Citation: Genomic Medicine 2007 1:9002
    Content type: Review Published on:

  19. The 3′ untranslated regions (3′ UTRs) of human protein-coding genes play a pivotal role in the regulation of mRNA 3′ end formation, stability/degradation, nuclear export, subcellular localisation and translati...

    Authors: Nadia Chuzhanova, David N. Cooper, Claude Férec and Jian-Min Chen
    Citation: Genomic Medicine 2007 1:9000
    Content type: Research Article Published on: