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The HUGO Journal

Official Journal of the Human Genome Organisation

Fig. 1 | Genomic Medicine

Fig. 1

From: Transcriptional activity of the RHOB gene is influenced by regulatory polymorphisms in its promoter region

Fig. 1

Cooperative regulation of the RHOB promoter SNPs rs585017 and rs2602160. (a) Location of the RHOB promoter polymorphisms as determined by DNA sequence analysis. CAAT- and TATA-boxes are indicated as is the transcriptional start site. (b, c) Influence of the promoter SNPs on the transcriptional activity of the RHOB in SW1353 cells (b) and in HeLa cells (c). The vectors pGL3-TA and pGL3-CG carry the wildtype- (T at the position −1285 and A at the position −165 bp) and the SNP-haplotyp (C at position −1285 and G at position −165), respectively. Each experiment was performed six times; relative luciferase units are given as mean ± SD

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