Skip to content


The HUGO Journal

Official Journal of the Human Genome Organisation

The HUGO Journal Cover Image


Sort by
Page 1 of 5
  1. Content type: Report

    In June 2014, the H3Africa Working Group on Ethics organised a workshop with members of over 40 research ethics committees from across Africa to discuss the ethical challenges raised in H3Africa research, and ...

    Authors: Jantina de Vries, Akin Abayomi, Katherine Littler, Ebony Madden, Sheryl McCurdy, Odile Ouwe Missi Oukem-Boyer, Janet Seeley, Ciara Staunton, Godfrey Tangwa, Paulina Tindana and Jennifer Troyer

    Citation: The HUGO Journal 2015 9:1

    Published on:

  2. Content type: Original research

    The Malays consist of various sub-ethnic groups which are believed to have different ancestral origins based on their migrations centuries ago. The sub-ethnic groups can be divided based on the region they inh...

    Authors: Wan Isa Hatin, Ab Rajab Nur-Shafawati, Ali Etemad, Wenfei Jin, Pengfei Qin, Shuhua Xu, Li Jin, Soon-Guan Tan, Pornprot Limprasert, Merican Amir Feisal, Mohammed Rizman-Idid and Bin Alwi Zilfalil

    Citation: The HUGO Journal 2014 8:5

    Published on:

  3. Content type: Original research

    The sequencing of two members of the Royal Kelantan Malay family genomes will provide insights on the Kelantan Malay whole genome sequences. The two Kelantan Malay genomes were analyzed for the SNP markers ass...

    Authors: Wan Khairunnisa Wan Juhari, Nur Aida Md Tamrin, Mohd Hanif Ridzuan Mat Daud, Hatin Wan Isa, Nurfazreen Mohd Nasir, Sathiya Maran, Nur Shafawati Abdul Rajab, Khairul Bariah Ahmad Amin Noordin, Nik Norliza Nik Hassan, Rick Tearle, Rozaimi Razali, Amir Feisal Merican and Bin Alwi Zilfalil

    Citation: The HUGO Journal 2014 8:4

    Published on:

  4. Content type: Brief report

    Opportunities provided by rapidly increasing access to educational resources, clinical and epidemiological data, DNA collections, cheaper technology and financial investment, suggest that researchers in sub-Sa...

    Authors: Endashaw Bekele, Walter F Bodmer, Neil Bradman, Ian W Craig, Julie Makani, Sue Povey and Charles Rotimi

    Citation: The HUGO Journal 2014 8:2

    Published on:

  5. Content type: Review

    Recently articles have been published disputing the main finding of the ENCODE project that the majority of the human genome exhibits biochemical indices of function, based primarily on low sequence conservati...

    Authors: John S Mattick and Marcel E Dinger

    Citation: The HUGO Journal 2013 7:2

    Published on:

  6. Content type: Review

    The concept of personalized medicine not only promises to enhance the life of patients and increase the quality of clinical practice and targeted care pathways, but also to lower overall healthcare costs throu...

    Authors: Sairamesh Jakka and Michael Rossbach

    Citation: The HUGO Journal 2013 7:1

    Published on:

  7. Content type: Review

    Fanconi Anemia (FA) is a rare disorder with incidence of 1in 350,000 births. It is characterized by progressive bone marrow failure leading to death of many patients in their childhood while development of can...

    Authors: Pallavi Shukla, Kanjaksha Ghosh and Babu R Vundinti

    Citation: The HUGO Journal 2012 6:1

    Published on:

  8. Content type: Review

    Since the development of technologies that can determine the base-pair sequence of DNA, the ability to sequence genes has contributed much to science and medicine. However, it has remained a relatively costly ...

    Authors: Sowmiya Moorthie, Christopher J. Mattocks and Caroline F. Wright

    Citation: The HUGO Journal 2011 5:9156

    Published on:

  9. Content type: Review

    Cis-acting polymorphisms that affect gene expression are now known to be frequent, although the extent and mechanisms by which such variation affects the human phenotype are, as yet, only poorly understood. Key s...

    Authors: Bryony L. Jones and Dallas M. Swallow

    Citation: The HUGO Journal 2011 5:9155

    Published on:

  10. Content type: Research article

    Post-Human Genome Project progress has enabled a new wave of population genetic research, and intensified controversy over the use of race/ethnicity in this work. At the same time, the development of methods f...

    Authors: Sarah E. Ali-Khan, Tomasz Krakowski, Rabia Tahir and Abdallah S. Daar

    Citation: The HUGO Journal 2011 5:9154

    Published on:

  11. Content type: Research article

    Angiotensin-I-converting enzyme (ACE) is known to be associated with human cardiovascular and psychiatric pathophysiology. We have undertaken a global survey of the haplotypes in ACE gene to study diversity and t...

    Authors: Shabana Farheen, Analabha Basu and Partha P. Majumder

    Citation: The HUGO Journal 2011 5:9153

    Published on:

  12. Content type: Research article

    In recent years, genome-sequencing projects of pathogens and humans have revolutionized microbial drug target identification. Of the several known genomic strategies, subtractive genomics has been successfully...

    Authors: Umashankar Vetrivel, Gurunathan Subramanian and Sudarsanam Dorairaj

    Citation: The HUGO Journal 2011 5:9152

    Published on:

  13. Content type: Research article

    We identified 531 and 616 putative HIF-1α target sites by ChIP-Seq in the cancerous cell line DLD-1 and the non-cancerous cell line TIG-3, respectively. We also examined the positions and expression levels of ...

    Authors: Kousuke Tanimoto, Katsuya Tsuchihara, Akinori Kanai, Takako Arauchi, Hiroyasu Esumi, Yutaka Suzuki and Sumio Sugano

    Citation: The HUGO Journal 2011 4:9150

    Published on:

  14. Content type: Review

    Genetic alterations can determine the natural history of cancer and its treatment response. With further advances in DNA sequencing technology, multiple novel genetic alterations will be discovered which could...

    Authors: K. L. Aung, R. E. Board, G. Ellison, E. Donald, T. Ward, G. Clack, M. Ranson, A. Hughes, W. Newman and C. Dive

    Citation: The HUGO Journal 2011 4:9149

    Published on:

  15. Content type: Research Article

    This paper explores young people’s attitudes to genetics. It describes a qualitative study involving a group of teenagers in a deprived South Wales valley town over a period of 18 months. The GAMY (Genetics an...

    Authors: Rachel Iredale, Kim Madden, Nicola Taverner, Juping Yu and Kevin McDonald

    Citation: The HUGO Journal 2011 4:9148

    Published on:

  16. Content type: Review Article

    Copy number variation is common in the human genome with many regions, overlapping thousands of genes, now known to be deleted or amplified. Aneuploidies and other forms of chromosomal imbalance have a wide ra...

    Authors: Adam J. de Smith, Anne L. Trewick and Alexandra I. F. Blakemore

    Citation: The HUGO Journal 2010 4:9144

    Published on:

Page 1 of 5