Official Journal of the Human Genome Organisation
Table 2 Comparing clinical profile of patients among the three ACE genotypes (Mean ± SD)
From: High dose Losartan and ACE gene polymorphism in IgA nephritis
DD n = 30 | ID n = 76 | II n = 101 | P value* | |
|---|---|---|---|---|
Sex (F:M) | 17:13 | 30:46 | 51:54 | |
Age at biopsy (years) | 34 ± 9 | 33 ± 11 | 32 ± 10 | NS |
Duration of trial (months) | 75 ± 2 | 75 ± 2 | 75 ± 3 | NS |
Hypertension (yes:no) | 17:13 | 38:39 | 49:52 | NS |
EGFR (ml/min) | ||||
Before | 58.6 ± 21.8 | 62.2 ± 22.3 | 61.3 ± 23.2 | NS |
After | 47.6 ± 28.6 | 46.3 ± 32.9 | 43.7 ± 30.9 | NS |
(P < 0.001) | (P < 0.001) | (P < 0.001) | ||
Decrease in eGFR (ml min−1year−1) | 1.8 ± 3.0 | 2.6 ± 3.5 | 2.6 ± 3.5 | NS |
Urinary protein (gm/day) | ||||
Before | 2.4 ± 1.4 | 2.2 ± 1.4 | 2.2 ± 1.2 | NS |
After | 1.5 ± 1.0 | 1.4 ± 1.0 | 1.6 ± 1.0 | NS |
(P < 0.002) | (P < 0.001) | (P < 0.001) | ||
Blood pressure (mmHg) | ||||
Systolic before | 134 ± 10 | 132 ± 11 | 133 ± 11 | NS |
Systolic after | 131 ± 9 | 128 ± 12 | 128 ± 10 | NS |
(P < 0.002) | (P < 0.001) | (P < 0.001) | ||
Diastolic before | 84 ± 6 | 84 ± 7 | 84 ± 7 | NS |
Diastolic after | 86 ± 6 | 82 ± 7 | 83 ± 6 | P = 0.021* |
NS | NS | NS | (between DD and ID) | |
Outcome | ||||
Non-ESRF | 23 | 65 | 93 | NS |
ESRF | 7 | 11 | 28 | |
Improvement in eGFR | ||||
Yes | 10 | 23 | 10 | NS |
No | 20 | 53 | 91 | |