Official Journal of the Human Genome Organisation
Table 1 Association of breast cancer risk factors between BRCA mutation carriers and non-carriers (N = 226)
From: Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer
BRCA Mutations | ||||||||
|---|---|---|---|---|---|---|---|---|
Carriers (N = 28)* | Non-carriers (N = 198)* | Unadjusted | ||||||
n | Col % | n | Col % | χ2 | P-value | OR† | 95% CI | |
Age first diagnosed with breast cancera | ||||||||
Age group: | ||||||||
<40 | 15 | 55.6 | 71 | 36.0 | 1.00** | |||
≥40 | 12 | 44.4 | 126 | 64.0 | 3.82 | 0.05 | 0.45 | (0.20, 1.02) |
Had ovarian cancer | ||||||||
No | 24 | 85.7 | 195 | 98.5 | 1.00 | |||
Yes | 4 | 14.3 | 3 | 1.5 | 13.33 | 0.005 | 10.83 | (2.29, 51.34) |
Alcohol: | ||||||||
No | 27 | 96.4 | 182 | 91.9 | 1.00** | |||
Yes | 1 | 3.6 | 16 | 8.1 | 0.72 | 0.40 | 0.42 | (0.05, 3.31) |
Smoking: | ||||||||
No | 26 | 92.9 | 184 | 92.9 | 1.00** | |||
Yes | 2 | 7.1 | 14 | 7.1 | <0.001 | 0.99 | 1.01 | (0.22, 4.70) |
Taking contraceptive pills/injection/patch: | ||||||||
No | 17 | 63.0 | 107 | 56.9 | 1.00** | |||
Yes | 10 | 37.0 | 81 | 43.1 | 0.35 | 0.55 | 0.78 | (0.34, 1.79) |
Taking hormonal replacement treatment: | ||||||||
No | 16 | 84.2 | 108 | 90.0 | 1.00** | |||
Yes | 3 | 15.8 | 12 | 10.0 | 0.57 | 0.45 | 1.69 | (0.43, 6.64) |
Taking infertility drug: | ||||||||
No | 25 | 100.0 | 175 | 96.2 | ||||
Yes | 0 | 0.0 | 7 | 3.8 | 0.99 | 1.00 | – | – |
Whether had breast feed a child: | ||||||||
No | 14 | 77.8 | 90 | 66.7 | 1.00** | |||
Yes | 4 | 22.2 | 45 | 33.3 | 0.90 | 0.34 | 0.57 | (0.18, 1.84) |
Menopause: | ||||||||
No | 14 | 50.0 | 103 | 52.0 | 1.00** | |||
Yes | 14 | 50.0 | 95 | 48.0 | 0.04 | 0.84 | 1.08 | (0.49, 2.39) |
Ever been pregnant: | ||||||||
No | 13 | 46.4 | 60 | 30.3 | 1.00** | |||
Yes | 15 | 53.6 | 138 | 69.7 | 2.92 | 0.09 | 0.50 | (0.23, 1.12) |