Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer

The HUGO Journal

Official Journal of the Human Genome Organisation

Table 4 Association between BRCA mutation carriers and breast cancer pathology

	BRCA mutations‡
	Carriers (N = 28) *		Non-Carriers (N = 239) *				Unadjusted
	n	Col %	n	Col %	χ²	P-value	OR†	95% CI
LVI (Lymphatic invasion):
Absent/suspicious^a	20	90.9	107	64.5			1.00**
Present	2	9.9	59	35.5	6.20	0.01	0.18	(0.04, 0.80)
Grade:
1 and 2	9	37.5	103	60.6			1.00**
3	15	62.5	67	39.4	4.59	0.03	2.56	(1.06, 6.19)
Type:
DCIS (Ductal carcinoma In Situ)	8	23.5	33	15.2			1.00**
Invasive	26	76.5	84	84.8	1.49	0.22	0.58	(0.24, 1.40)
Stage:
Stage 0	8	25.8	32	15.7
Stage 1	10	32.3	56	27.5			1.00**
Stage 2, 3, and 4	13	41.9	116	56.9	1.80	0.30	0.63	(0.26, 1.52)
T stage (Tumor size):
T0	8	24.2	30	14.6
T1	16	48.5	74	36.1			1.00**
T2, 3 and 4	9	27.3	84	41.0	6.50	0.05	0.41	(0.17, 0.98)
N stage (Lymph node involvement):
N0	22	75.9	130	64.0			1.00**
N1, 2, and 3	7	24.1	73	36.0	1.57	0.21	0.57	(0.23, 1.39)
M stage (Metastatic):
M0	32	100.0	201	95.7
M1	0	0	9	4.3	1.42	0.23	–	–
ER (Estrogen receptor):
Positive	15	48.4	141	72.3			1.00**
Negative	16	51.6	54	27.7	7.16	0.007	2.78	(1.28, 5.88)
PR (Progesterone receptor):
Positive	11	36.7	112	58.6			1.00**
Negative	19	63.3	79	41.4	5.07	0.02	2.44	(1.10, 5.56)
Cerb 2 (Protein of HER2 Oncogene):
Positive	9	31.0	87	49.2			1.00**
Negative	20	69.0	90	50.8	3.29	0.07	2.13	(0.93,5.00)
Triple negative (ER⁻/PR⁻/Cerb2⁻):
No	15	51.7	131	74.4			1.00**
Yes	14	48.3	45	25.6	6.26	0.01	2.11	(1.22, 5.88)
Ki67 index (% of growing cells):
<12%	6	60.0	28	50.9			1.00**
>12%	4	40.0	27	49.1	0.28	0.60	0.69	(0.18,2.70)

^aThere were two BRCA non-carriers and two BRCA carriers with LVI suspicious
Bold figure: Significant at <0.05
* Values may not sum to 100% because of missing data
** Referent
‡ Includes 41 bilateral cancers in non-mutation carriers (14%) and 9 bilateral cancers in mutation carriers (24%)
† Univariate Odd Ratios comparing “Carriers” versus “Non-carriers” (reference group)