Official Journal of the Human Genome Organisation
Table 1 Clinical and angiographic findings before and after VEGF gene therapy
Clinical history and findings before gene therapy | Outcomes after gene therapy (2 months) | ||||||
|---|---|---|---|---|---|---|---|
No. | Gender | Age (years) | Diagnosis | Signs/symptoms | Angiographic findings | Signs/symptoms | Angiographic findings |
1 | Female | 46 | Thromboangiitis obliterans; critical ischaemia of the left foot | Claudication at 200 m, resting pain, toe gangrene (digits IV–V) | Complete occlusion of the superficial femoral artery, without blood supply in the popliteal artery through collateral vessels, perfusion only in the distal half of the peroneal artery | Claudication at 350 m, resting pain decreased, gangrene area reduced (digit V) | No detectable changes |
2 | Female | 35 | Chronic obliterative arteriopathy of the right lower limb, stage II B; critical ischaemia of the right foot | Claudication at 150 m, resting pain, toe gangrene (digit I) | Occlusion in the proximal region of the right anterior tibial artery, occlusion in the middle region of the posterior tibial artery | Claudication at 450 m, resting pain decreased, gangrene area reduced | No detectable changes |
3 | Male | 53 | Chronic obliterative arteriopathy of the left lower limb, stage II B | Claudication at 50 m, resting pain | Chronic bilateral occlusion of the superficial femoral artery, occlusion of the left popliteal artery and left calf arteries. | Claudication at 200 m, resting pain decreased | Visible new formed collateral vessels at the level of the calf |