Albers M, Fratezi AC, DeLuccia N (1992) Assessment of quality of life of patients with severe ischaemia as a result of infrainguinal arterial occlusive disease. J Vasc Surg 16:54–59
Article
PubMed
CAS
Google Scholar
Anghel A, Sirbu IO, Marian C, Tamas L, Motoc M (2002) Introduction to gene therapy; Mirton Publishing House, Timisoara, Romania
Bacic M, Edwards NA, Merrill MJ (1995) Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues—Short Communication. Growth Factors 12:11–15
Article
PubMed
CAS
Google Scholar
Baumgartner I, Rauh G, Pieczek A, Wuensch D, Magner M, Kearney M, Schainfeld R, Isner JM (2000) Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor. Ann Intern Med 132(11):880–884
Article
PubMed
CAS
Google Scholar
Blau MH, Banfi A (2001) The well-tempered vessel. Nat Med 7:532–534
Article
PubMed
CAS
Google Scholar
Brown AL, Juergens JL (1972) Arteriosclerosis and atherosclerosis. In: Allen EV et al (eds) Peripheral vascular disease. Saunders, Philadelphia, pp 57–66
Google Scholar
Dantz D, Bewersdorf J, Fruehwald-Schultes B, Kern W, Jelkmann W, Born J, Fehm HL, Peters A (2002) Vascular endothelial growth factor: a novel endocrine defensive response to hypoglycemia. J Clin Endocr Metab 87:835–840
Article
PubMed
CAS
Google Scholar
Eskelinen E, Lepantalo M, Hietala EM, Sell H, Kauppila L, Maenpaa I, Pitkanen J, Salminen-Peltola P, Leutola S, Eskelinen A, Kivioja A, Tukiainen E, Lukinmaa A, Brasken P, Railo M (2004) Lower limb amputations in Southern Finland in 2000 and trends up to 2001. Eur J Vasc Endovasc Surg 27:193–200
Article
PubMed
CAS
Google Scholar
Freedman SB, Vale P, Kalka C, Kearney M, Pieczek A, Symes J, Losordo D, Isner JM (2002) Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA. Hum Gene Ther 13:1595–1603
Article
PubMed
CAS
Google Scholar
Gerritsen ME (2005) HGF and VEGF: a dynamic duo. Circ Res 96:272–273
Article
PubMed
CAS
Google Scholar
Gordon T, Kannel WB (1972) Predisposition to atherosclerosis in the head, heart, and legs. The Framingham study. JAMA 221:661–666
Article
PubMed
CAS
Google Scholar
Helmlinger G, Endo M, Ferrara N, Hlatky L, Jain RK (2000) Formation of endothelial cell networks. Nature 405:139–141
Article
PubMed
CAS
Google Scholar
Isner JM, Baumgartner I, Rauh G, Schainfeld R, Blair R, Manor O, Razvi S, Symes JF (1998) Treatment of thromboangiitis obliterans (Buerger’s disease) by intramuscular gene transfer of vascular endothelial growth factor: preliminary clinical results. J Vasc Surg 28:964–973
Article
PubMed
CAS
Google Scholar
Isner JM, Pieczek A, Schainfield R, Blair R, Haley L, Asahara T, Rosenfield K, Razvi S, Walsh K, Symes JF (1996) Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 348:370–374
Article
PubMed
CAS
Google Scholar
Isner JM, Ropper A, Hirst K (2001) VEGF gene transfer for diabetic neuropathy. Hum Gene Ther 12:1593–1594
PubMed
CAS
Google Scholar
Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246:1309–1312
Article
PubMed
CAS
Google Scholar
Kusumanto YH, Van Weel V, Mulder NH, Smit AJ, Van Den Dungen JJAM, Hooymans JMM, Sluiter WJ, Tio RA, Quax PHA, Gans ROB, Dullaart RPF, Hospers GAP (2006) Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double blind randomized trial. Hum Gene Ther 17:683–691
Article
PubMed
CAS
Google Scholar
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306–1309
Article
PubMed
CAS
Google Scholar
Poltorak Z, Cohen T, Sivan R, Kandelis Y, Spira G, Vlodavsky I, Keshet E, Neufeld G (1997) VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 272:7151–7158
Article
PubMed
CAS
Google Scholar
Rajagopalan S, Shah M, Luciano A, Crystal R, Nabel EG (2001) Adenovirus-mediated gene transfer of VEGF121 improves lower-extremity endothelial function and flow reserve. Circulation 104:753–755
Article
PubMed
CAS
Google Scholar
Schratzberger P, Schratzberger G, Silver M, Curry C, Kearney M, Magner M, Alroy J, Adelman LS, Weinberg DH, Ropper AH, Isner JM (2000) Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nat Med 6:405–413
Article
PubMed
CAS
Google Scholar
Schratzberger P, Walter DH, Rittig K, Bahlmann FH, Pola R, Curry C, Silver M, Krainin JG, Weinberg DH, Ropper AH, Isner JM (2001) Reversal of experimental diabetic neuropathy by VEGF gene transfer. J Clin Invest 107:1083–1092
Article
PubMed
CAS
PubMed Central
Google Scholar
Shyu KG, Chang H, Wang BW, Kuan P (2003) Intramuscular vascular endothelial growth factor gene therapy in patients with chronic critical leg ischaemia. Am J Med 114:85–92
Article
PubMed
CAS
Google Scholar
Simovic D, Isner JM, Ropper AH, Pieczek A, Weinberg DH (2001) Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischaemia. Arch Neurol 58:761–768
Article
PubMed
CAS
Google Scholar
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92:735–745
Article
PubMed
CAS
Google Scholar
Stapanavatr W, Ungkittpaiboon W, Karnjanabatr B (2004) Conservative regimen for chronic critical limb ischemia. J Med Assoc Thai 87(3):310–318
PubMed
Google Scholar
Takeshita S, Isshiki T, Tanaka E, Eto K, Miyazawa Y, Tanaka A, Shinozaki Y, Hyodo K, Ando M, Kubota M, Tanioka K, Umetani K, Ochiai M, Sato T, Mori H, Miyashita H (1997) Use of synchrotron radiation microangiography to assess development of small collateral arteries in a rat model of hindlimb ischaemia. Circulation 95:805–808
Article
PubMed
CAS
Google Scholar
Takeshita S, Pu LQ, Stein LA, Sniderman AD, Bunting S, Ferrara N, Isner JM, Symes JF (1994) Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of persistent limb ischaemia. Circulation 90(5pt2):II228–II234
PubMed
CAS
Google Scholar
Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, Glazer N, Holash J, McDonald DM, Yancopoulos GD (2000) Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6:460–463
Article
PubMed
CAS
Google Scholar
Thurston G, Suri C, Smith K, McClain J, Sato TN, Yancopoulos GD, McDonald DM (1999) Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286:2511–2514
Article
PubMed
CAS
Google Scholar
Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA (1991) The human gene for vascular endothelial growth factor: multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266:11947–11954
PubMed
CAS
Google Scholar
Veves A, King GL (2001) Can VEGF reverse diabetic neuropathy in human subjects? J Clin Invest 107:1215–1218
Article
PubMed
CAS
PubMed Central
Google Scholar
Wolfe JHN (1986) Defining the outcome of critical ischaemia: a one year prospective study. Br J Surg 73:321–328
Article
Google Scholar