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Official Journal of the Human Genome Organisation

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Page 3 of 3

  1. Content type: Research Article

    5α-Androstane-3α,17β-diol (3α-diol) is reduced from the potent androgen, 5α-dihydrotestosterone (5α-DHT), by reductive 3α-hydroxysteroid dehydrogenases (3α-HSDs) in the prostate. 3α-diol is recognized as a wea...

    Authors: Mikhail G. Dozmorov, Qing Yang, Adam Matwalli, Robert E. Hurst, Daniel J. Culkin, Bradley P. Kropp and Hsueh-Kung Lin

    Citation: Genomic Medicine 2008 1:9018

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  2. Content type: Review

    The concept of ‘evidence-based medicine’ dates back to mid-19th century or even earlier. It remains pivotal in planning, funding and in delivering the health care. Clinicians, public health practitioners, heal...

    Authors: Dhavendra Kumar

    Citation: Genomic Medicine 2007 1:9013

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  3. Content type: Research Article

    A highly-parallel yeast functional assay, capable of screening approximately 100–1,000 mutants in parallel and designed to screen the activity of transcription activator proteins, was utilized to functionally ...

    Authors: Joshua Merritt, Kim G. Roberts, James A. Butz and Jeremy S. Edwards

    Citation: Genomic Medicine 2007 1:9011

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  4. Content type: Research Article

    Hyperproliferative epidermal disorders range from benign hyperplasias such as psoriasis to basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), the two most common cancers in the US. While they all ar...

    Authors: Min Fang, Sue Ann Wee, Karyn Ronski, Hongran Fan, Shiying Tao and Qun Lin

    Citation: Genomic Medicine 2007 1:9010

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  5. Content type: Research Article

    We report on a patient with severe mental retardation, dysmorphic features as well as juvenile idiopathic arthritis. G-banding indicated two independent karyotypic anomalies in this patient: an interstitial de...

    Authors: Sabine Leybrand, Eva Rossier, Gotthold Barbi, David N. Cooper and Hildegard Kehrer-Sawatzki

    Citation: Genomic Medicine 2007 1:9008

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  6. Content type: Research Article

    Array based comparative genomic hybridisation (aCGH) is a powerful technique for detecting clinically relevant genome imbalance and can offer 40 to > 1000 times the resolution of karyotyping. Indeed, idiopathi...

    Authors: Sarah Wordsworth, James Buchanan, Regina Regan, Val Davison, Kim Smith, Sara Dyer, Carolyn Campbell, Edward Blair, Eddy Maher, Jenny Taylor and Samantha J. L. Knight

    Citation: Genomic Medicine 2007 1:9005

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  7. Content type: Research Article

    Protein p53 is the tumor suppressor involved in cell cycle control and apoptosis. There are several polymorphisms reported for p53 which can affect important regions involved in protein tumor suppressor activi...

    Authors: Diogo André Pilger, Patrícia Luciana da Costa Lopez, Fábio Segal and Sandra Leistner-Segal

    Citation: Genomic Medicine 2007 1:9007

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  8. Content type: Research Article

    The present study focuses on the application of a therapeutic strategy in patients with chronic severe lower limb ischaemia using a plasmid vector encoding the vascular endothelial growth factor (phVEGF165). It h...

    Authors: Andrei Anghel, Bogdan Mut-Vitcu, Lorand Savu, Catalin Marian, Edward Seclaman, Raluca Iman, Adriana-Maria Neghina and Stefan I. Dragulescu

    Citation: Genomic Medicine 2007 1:9006

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  9. Content type: Review

    LINE-1 or L1 has driven the generation of at least 10% of the human genome by mobilising Alu sequences. Although there is no doubt that Alu insertion is initiated by L1-dependent target site-primed reverse transc...

    Authors: Jian-Min Chen, Claude Férec and David N. Cooper

    Citation: Genomic Medicine 2007 1:9002

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  10. Content type: Research Article

    The 3′ untranslated regions (3′ UTRs) of human protein-coding genes play a pivotal role in the regulation of mRNA 3′ end formation, stability/degradation, nuclear export, subcellular localisation and translati...

    Authors: Nadia Chuzhanova, David N. Cooper, Claude Férec and Jian-Min Chen

    Citation: Genomic Medicine 2007 1:9000

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